MicroRNAs

Small double-stranded, non-protein coding RNAs, 21-25 nucleotides in length generated from single-stranded microRNA gene transcripts by the same RIBONUCLEASE III, Dicer, that produces small interfering RNAs (RNA, SMALL INTERFERING). They become part of the RNA-INDUCED SILENCING COMPLEX and repress the translation (TRANSLATION, GENETIC) of target RNA by binding to homologous 3'UTR region as an imperfect match. The small temporal RNAs (stRNAs), let-7 and lin-4, from C. elegans, are the first 2 miRNAs discovered, and are from a class of miRNAs involved in developmental timing.

Also Known As:

MicroRNA; miRNA; miRNAs; Micro RNA; RNA, Micro; Primary MicroRNA; Primary miRNA; pre-miRNA; pri-miRNA; MicroRNA, Primary; Temporal RNA, Small; miRNA, Primary; pre miRNA; pri miRNA; RNA, Small Temporal; Small Temporal RNA; stRNA

Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleic Acids: 12179
  - RNA: 73192
    - Untranslated RNA: 3035
      - Small Untranslated RNA: 586
        MicroRNAs: 69499
    - Antisense RNA: 1632
      - MicroRNAs: 69499
- Antisense Elements (Genetics): 29
  - Antisense RNA: 1632
    - MicroRNAs: 69499

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Disease

Drug/Important Bio-Agent (IBA)